| Two-Handed Weapon Specialization Rank 4 | Physical | Instant |
| Two-Handed Weapon Specialization Rank 5 | Physical | Instant |
| Uber Heal Over Time | Holy | Instant |
| Uldaman Key Staff | Physical | 5 sec cast |
| Ultra Deconsolodation Zapper | Physical | 5 sec cast |
| Ultra-Flash Shadow Reflector | Physical | 45 sec cast |
| Ultra-Spectropic Detection Goggles | Physical | 50 sec cast |
| Ultrasafe Transporter - Gadgetzan | Physical | 45 sec cast |
| Ultrasafe Transporter - Toshley's Station | Physical | 3 sec cast |
| Unarmed | Physical | Instant |
| Unbanish Azaloth | Physical | 2 sec cast |
| Unbreakable Will Rank 1 | Physical | Instant |
| Unbreakable Will Rank 2 | Physical | Instant |
| Unbreakable Will Rank 3 | Physical | Instant |
| Unbreakable Will Rank 4 | Physical | Instant |
| Unbreakable Will Rank 5 | Physical | Instant |
| Unbridled Wrath Rank 1 | Physical | Instant |
| Unbridled Wrath Rank 1 | Physical | Instant |
| Unbridled Wrath Rank 2 | Physical | Instant |
| Unbridled Wrath Rank 3 | Physical | Instant |
| Unbridled Wrath Rank 4 | Physical | Instant |
| Unbridled Wrath Rank 5 | Physical | Instant |
| Undead Horsemanship Passive | Physical | Instant |
| Undead Slayer 30 | Physical | Instant |
| Undead Slayer 45 | Physical | Instant |
| Undead Slayer 60 | Physical | Instant |
| Undead Slayer 66 | Physical | Instant |
| Undead Slayer 81 | Physical | Instant |
| Undercity Gift of Friendship | Physical | Instant |
| Undermine Clam Chowder | Physical | 3 sec cast |
| Underspore Pod | Physical | Instant |
| Underwater Breathing Racial Passive | Physical | Instant |
| Undo Crowd Control Rogue | Physical | Instant |
| Unending Breath | Shadow | Instant |
| Unholy Aura | Physical | Instant |
| Unholy Power Rank 1 | Physical | Instant |
| Unholy Power Rank 2 | Physical | Instant |
| Unholy Power Rank 3 | Physical | Instant |
| Unholy Power Rank 4 | Physical | Instant |
| Unholy Power Rank 5 | Physical | Instant |
| Universal Remote | Physical | Instant |
| Unleashed Fury Rank 1 | Physical | Instant |
| Unleashed Fury Rank 2 | Physical | Instant |
| Unleashed Fury Rank 3 | Physical | Instant |
| Unleashed Fury Rank 4 | Physical | Instant |
| Unleashed Fury Rank 5 | Physical | Instant |
| Unleashed Rage Rank 1 | Physical | Instant |
| Unleashed Rage Rank 1 | Physical | Instant |
| Unleashed Rage Rank 2 | Physical | Instant |
| Unleashed Rage Rank 3 | Physical | Instant |